Cristiano Ronaldo became the first player to score 50 goals in Serie A, La Liga and the Premier League as his double against Lazio put Juventus on the brink of the Serie A title.
Juve are eight points clear of Inter Milan and need four points to clinch a ninth consecutive title.
Ronaldo opened the scoring with a penalty and tapped in a second from Paulo Dybala's pass.
Ciro Immobile scored a penalty to pull one back for fourth-placed Lazio.
Juventus, meanwhile, need at least four points to secure the title, Juventus next faces Udinese on Thursday.
Game Highlights
