Juventus got off to a fast start when Danilo and Gonzalo Higuain scored in the opening 12 minutes, but Filip Djuricic's goal in the 29th minute signalled the start of a spirited fightback by the home side.
Goals from Domenico Berardi and Francesco Caputo put Sassuolo 3-2 up early in the second half but Alex Sandro produced a bullet header in the 64th minute to secure a point for Juve, who are chasing their ninth league title in a row.
Having taken just two points from their last three games, Juventus are on 77 points with five games left, seven ahead of second-placed Atalanta - who thumped Brescia 6-2 on Tuesday.
